Actin dynamics in cell migration
نویسندگان
چکیده
منابع مشابه
Actin Dynamics: Cell Migration Takes a New Turn with Arpin
Accurate cell migration requires intricate control over the actin cytoskeleton. Recent work has identified an Arp2/3-interacting protein called Arpin, which restricts the rate of actin polymerization and is the latest component in the steadily expanding protein repertoire that controls cell migration.
متن کاملMitochondrial Ca2+ uptake controls actin cytoskeleton dynamics during cell migration
Intracellular Ca2+ signaling regulates cell migration by acting on cytoskeleton architecture, cell directionality and focal adhesions dynamics. In migrating cells, cytosolic Ca2+ pool and Ca2+ pulses are described as key components of these effects. Whereas the role of the mitochondrial calcium homeostasis and the Mitochondria Cacium Uniporter (MCU) in cell migration were recently highlighted i...
متن کاملIntegrins in cell migration--the actin connection.
The connection between integrins and actin is driving the field of cell migration in new directions. Integrins and actin are coupled through a physical linkage, which provides traction for migration. Recent studies show the importance of this linkage in regulating adhesion organization and development. Actin polymerization orchestrates adhesion assembly near the leading edge of a migrating cell...
متن کاملCell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin
1 Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037 2 Program on Cell Adhesion, The Burnham Institute, La Jolla, CA 92037 3 Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218 4 Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway...
متن کاملDisentangling Membrane Dynamics and Cell Migration; Differential Influences of F-actin and Cell-Matrix Adhesions
Cell migration is heavily interconnected with plasma membrane protrusion and retraction (collectively termed "membrane dynamics"). This makes it difficult to distinguish regulatory mechanisms that differentially influence migration and membrane dynamics. Yet such distinctions may be valuable given evidence that cancer cell invasion in 3D may be better predicted by 2D membrane dynamics than by 2...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Essays in Biochemistry
سال: 2019
ISSN: 0071-1365,1744-1358
DOI: 10.1042/ebc20190015